I have several perilla/shiso plants grown from a batch of seeds. Right now all of them look spotty and yellowish rather than deep green like those you get from stores. Is this a disease or are they missing nutrients / particular minerals?
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Perilla is an annual herb and can be subject to rust which shows as rust coloured spots.
As the spots on the leaves in the picture are light coloured it looks like aphids or spider mites which suck sap.
Spider mites are the size of a grain of salt and cluster on the undersides of the leaves. You may need a magnifying glass to see them. They make a web when populations get large and can spread to other plants.
Aphids are much larger and come in a variety of colours.
Both can be controlled with at least three applications of soap and water at five to six day intervals applied at a ratio of 25 ml of dish soap per litre of water.
As these plants are grown to be eaten and they are annual seedlings I recommend either planting them outside and hoping for the best or throwing them out. Most seedlings are too delicate for the soap and water method of control.