The ample fruit is a good sign. It may be in need of a bit more water or a bit more nutrient to support the fruit growth. It may be drawing from the foliage to support the fruit. And check around the base & remove any old leaves etc to help air flow. Would avoid pruning until its dormant, and then only a mild prune.
If the fruit size has changed just this season is significant. Often if theres a blueberry v there will be rapid deterioration of an entire branch, or the fruit clusters and branch tips with fruit. The pattern looks outwardly somewhat like either mosaic or scorch, but the way the colour has been withdrawn from the leaves isnt so typical of scorch, nor mosaic; the lack of sweetness may reflect indicate inadequate energy available to the fruit, from whatever cause.
Could be a relatively new ailment. Maybe check the stems and around the roots, and check for aphids, or something in the roots. They can weaken the plant and make it less resistant. And if there are some aphids or something, they can spread things to the other bushes in addition to weakening that bush. If some branches do entirely deteriorate, they should be removed, and a stronger prune indicated.