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Jul 15, 2018 at 15:56 comment added user22542 You might try very careful application of a herbicide spray (glyphosate) on the foliage. I find that, although it takes several days to weeks to kill them, the herbicide is systemic and does do them in. Be careful with your other plants though. I use it judiciously with poison ivy and it works.
Jul 15, 2018 at 15:38 comment added Jason Rubinstein That is very interesting, as concerning as it may be! I've been very aggressively staying on top of the Canadian thistle, and have nearly eradicated it. But according to the Wikipedia article, I might have promoted growth of the horse nettle by removing competing weeds!
Jul 15, 2018 at 13:43 history answered user22542 CC BY-SA 4.0