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I'm fighting a losing battle with these plants (pictured). No idea what they are called, but I always just call them "stickers".

Stickers!

I tried pulling them with the sticker pods intact and disposing of them to prevent them from spreading as much as possible, but that hasn't been effective. I'm thinking about applying a herbicide whenever I see a patch of them, but I'm thinking that by the time they have the seed pods developed it might be too late to do any good because the next generation is on the way.

My question is this: Will spraying herbicides (such as RoundUp) "kill" the sticker seed pods and prevent them from germinating in addition to killing the plant they are attached to?

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Those look like sand burrs. For tackweed, we used a scorched earth technique: roundup to kill everything, water until the seeds sprouted, roundup to kill everything, again and again, until the tackweed quit coming up. Then we planted with what we wanted. –  thursdaysgeek Oct 8 '12 at 19:48

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Round Up is a herbicide which kill 'through the green'. The best time to apply is when the plant is growing strongly, the soil is damp, and the weather reasonably fair and not windy. Spray all stems till run off. Repeat applications might be necessary, but if you treat the plant before it flowers and sets seed, then it won't flower and set seed. Once the seeds are formed, Round up will not have any effect on them.

A word about Round Up - try to find glyphosate instead. This is the active ingredient in Round Up without the other surfactants and ingredients which have an impact on the environment. Glyphosate bought as a generic is cheaper, and when mixing it with water to spray or apply by can, adding a dash of washing up liquid helps it to penetrate plant tissues.

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The trouble is, the plant looks so similar to the grass around it, I have a hard time spotting it before it seeds. –  JohnFx Oct 6 '12 at 17:24
    
Have you tried digging it out, specially at this stage with the seeds in place? –  Bamboo Oct 6 '12 at 17:56

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